The constant struggle between Eddie Brock and the symbiote highlights the complex nature of their relationship, exploring how two distinct entities must learn to coexist while maintaining their individual identities. This internal conflict becomes particularly evident as Eddie tries to control the symbiote's growing hunger and violent tendencies.

Throughout the collection, Venom wrestles with his position as an anti-hero, attempting to do good while fighting his naturally violent instincts. The introduction of characters like the Jury and his confrontations with Ben Reilly force Venom to question his methods and motivations.

The various threats faced by Venom, from the Xenophage to Dr. Paine, demonstrate the character's remarkable ability to adapt and survive. This theme is reinforced through the symbiote's constant evolution and the challenges of maintaining control over its increasing hunger.